Extracellular Superoxide Dismutase in Pulmonary Fibrosis

Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis.

Bleomycin administration results in well-described intracellular oxidative stress that can lead to pulmonary fibrosis. The role of alveolar interstitial antioxidants in this model is unknown. Extracellular superoxide dismutase (EC-SOD) is the primary endogenous extracellular antioxidant enzyme and is abundant in the lung. We hypothesized that EC-SOD plays an important role in attenuating bleomy...

Extracellular Superoxide Dismutase

Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that previously has been demonstrated to be the major superoxide dismutase of human extracellular fluids. The occurrence of this enzyme in various human tissues that were removed from two accidental death victims and in 19 different human cultured cell lines was determined. All investigated tissues were found to c...

TNF LEUKOCYTE-DERIVED EXTRACELLULAR SUPEROXIDE DISMUTASE IN PULMONARY DISEASE by

Inactive extracellular superoxide dismutase disrupts secretion and function of active extracellular superoxide dismutase.

Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that protects cells and tissues from extracellular damage by eliminating superoxide anion radicals produced during metabolism. Two different forms of EC-SOD exist, and their different enzyme activities are a result of different disulfide bond patterns. Although only two folding variants have been discovered so far, five foldin...

Expression of Extracellular Superoxide Dismutase in Atherosclerosis

We characterized a novel form of extracellular superoxide dismutase (ecSOD) in atherosclerotic vessels. Specific activity and protein expression of ecSOD was increased twoto threefold in apo E–deficient compared with control aortas. RNase protection assays demonstrated that the expected ecSOD transcript was not increased in either apo E–deficient mice or cholesterol-fed LDL receptor–deficient m...